Excedrin

Odds are, if you take two Excedrin Migraine tablets at 4:30 in the afternoon, you'll be up at 2 a.m. watching QVC and scrubbing your floorboards with 409 and a toothbrush.

(note: for those of us who suffer from migraines, don't even bother with any kind of Excedrin.  My migraines simply laugh at it.  Bring on the Oxycodone, Xanax and a hammer.)